CDI is a safe, mild alternative to phosgene — widely used across pharmaceutical, polymer, and fine-chemical industries.
Activates carboxylic acids to form amides and esters in peptide coupling reactions.
Key reagent in API manufacturing, especially for carbamates, ureas, and heterocyclic drug scaffolds.
Used as a phosgene substitute in polycarbonate and polyurethane chemistry.
Mild, efficient coupling agent for selective acylation of alcohols, amines, and thiols.
Synthesis of carbamate-based pesticides, herbicides, and crop protection intermediates.
Surface functionalization of beads, resins, and biomolecule conjugation in life sciences.
Manufactured to pharmaceutical-grade standards with full COA, MSDS, and batch traceability.
| Product Name | 1,1'-Carbonyldiimidazole (CDI) |
| Synonyms | N,N'-Carbonyldiimidazole; CDI; Carbonyl diimidazole |
| CAS Number | 530-62-1 |
| EC Number | 208-488-1 |
| Molecular Formula | C₇H₆N₄O |
| Molecular Weight | 162.15 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity (HPLC) | ≥ 99.0% |
| Melting Point | 115 – 120 °C |
| Solubility | Soluble in THF, DCM, DMF, acetonitrile |
| Moisture | ≤ 0.5% |
| Storage | Sealed, dry, cool (2–8 °C), under inert gas |
CAS No. 530-62-1 identifies 1,1′-Carbonyldiimidazole (CDI) — a high-purity coupling and activating reagent manufactured and exported worldwide by MT Chemtech.
| CAS Number | 530-62-1 |
| EINECS / EC | 208-488-1 |
| Formula | C₇H₆N₄O |
| Molecular Weight | 162.15 g/mol |
| HS Code | 29331990 |
| UN Number | Not regulated (moisture sensitive) |
| Purity | ≥ 99.0% (HPLC) |
| Appearance | White to off-white crystalline powder |
MT Chemtech ships 1,1′-Carbonyldiimidazole (CAS 530-62-1) globally in moisture-sealed fiber drums (25 kg), HDPE bottles, and amber glass packs — every container sealed under nitrogen with desiccant and double PE liners. Request a quotation, COA, or MSDS directly.
Common search terms for this CAS number
Download or request product documents for Carbonyldiimidazole (CDI) CAS 530-62-1. All certificates are batch-traceable and issued under ISO 9001:2015.
Batch-specific purity, assay, moisture, melting point, and HPLC chromatogram with every shipment.
Comprehensive safety, handling, storage, first-aid, fire-fighting, and transport classification data.
Detailed specifications, solubility profiles, compatibility notes, and recommended storage conditions.
Generic MSDS and TDS are available on request. Batch-specific COAs are generated per lot and emailed directly.
CDI is moisture-sensitive — every container is sealed under inert nitrogen with desiccant and double liners for long-haul shipping. Minimum order quantity starts at 1 MT.
We export Carbonyldiimidazole to 40+ countries with full export documentation, hazardous-goods compliance, and air- or sea-freight options.
USA, Canada, Mexico
Germany, UK, France, Italy, Spain, Netherlands
Japan, South Korea, India, Singapore, Australia
UAE, Saudi Arabia, Israel, Turkey
Brazil, Argentina, Chile, Colombia
South Africa, Egypt, Morocco
With 20 metric tons of monthly production capacity, MT Chemtech is a leading manufacturer, supplier, and exporter of Carbonyldiimidazole to major markets worldwide.
Direct supply to pharmaceutical & biotech industries
Regulatory-compliant exports to EU & UK markets
Bulk shipments to API & chemical manufacturers
A curated review of recent process-chemistry literature where 1,1′-Carbonyldiimidazole (CDI) is the key reagent on commercial / multi-ton scale — replacing phosgene, triphosgene, and acid chlorides.
Oral Factor Xa anticoagulant (Xarelto®, Bayer/J&J) — blockbuster antithrombotic
Role of CDI: CDI is used to construct the central 2-oxo-1,3-oxazolidine (morpholinone-linked oxazolidinone) carbamate ring by cyclising a 1,2-amino alcohol intermediate.
Oxazolidinone antibiotic (Zyvox®, Pfizer) for resistant Gram-positive infections
Role of CDI: CDI cyclises the (R)-3-fluoro-4-morpholinyl-anilino-1,2-diol to install the oxazolidin-2-one pharmacophore in commercial-scale process routes.
Direct thrombin inhibitor anticoagulant (Pradaxa®, Boehringer Ingelheim)
Role of CDI: CDI mediates amide coupling between the benzimidazole-acetic acid and the N-(2-pyridyl)-β-alanine ethyl ester fragment in the manufacturing route.
Immunomodulatory anticancer drugs (Revlimid®, Pomalyst®, Celgene/BMS) for multiple myeloma
Role of CDI: CDI activates glutamic-acid derivatives to close the glutarimide ring under mild conditions, replacing phosgene/triphosgene in commercial processes.
Angiotensin-II receptor blocker (Benicar®, Daiichi Sankyo) — antihypertensive
Role of CDI: CDI activates the medoxomil (4-methyl-2-oxo-1,3-dioxol-4-yl)methyl carbonate prodrug ester onto the tetrazole-biphenyl-imidazole carboxylic acid.
Second-generation H₁-antihistamine (Bilaxten®, Faes Farma)
Role of CDI: CDI couples 2-[4-(2-aminoethyl)phenyl]-2-methylpropanoic acid with the 2-ethoxy-benzimidazole-piperidine fragment in the API route.
Factor Xa inhibitor anticoagulant (Eliquis®, BMS/Pfizer)
Role of CDI: CDI enables the lactam carbamoyl coupling forming the 4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine carboxamide on multi-ton manufacture.
Cholesterol-absorption inhibitor (Zetia®, Merck)
Role of CDI: CDI activates the (S)-3-hydroxy-3-(4-fluorophenyl)propanoic acid for stereoselective β-lactam formation in commercial routes.
Phosgene-free industrial polymers, coatings & medical-grade resins
Role of CDI: CDI is the leading non-phosgene carbonyl source for chain-extension of diols/diamines, producing aliphatic polycarbonates and polyureas at ton scale.
1,1′-Carbonyldiimidazole reacts with carboxylic acids to form acyl imidazolides (R–C(=O)–Im), with alcohols to form imidazole carbamates / carbonates, and with amines to form ureas and isocyanates. Imidazole is the only by-product, making CDI a green, safe substitute for phosgene, COCl₂, triphosgene and acid chlorides at commercial scale.
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Everything you need to know about Carbonyldiimidazole (CDI) CAS 530-62-1 — from product specifications and applications to ordering and shipping.
Carbonyldiimidazole, also known as 1,1′-Carbonyldiimidazole or CDI, is a versatile coupling and activating reagent used in organic synthesis. CAS 530-62-1 is its unique Chemical Abstracts Service registry number. CDI is widely used as a safe, solid substitute for toxic phosgene in peptide synthesis, pharmaceutical manufacturing, and polymer chemistry.
MT Chemtech is a leading manufacturer and supplier of Carbonyldiimidazole (CDI) CAS 530-62-1 in India, with a monthly production capacity of 20 metric tons. We supply pharmaceutical-grade CDI with ≥99.0% HPLC purity to customers in the USA, Europe, China, and over 40 countries worldwide.
Our minimum order quantity (MOQ) for Carbonyldiimidazole starts at 1 metric ton (MT). We also supply 5 MT, 10 MT, and 20 MT batches, as well as custom quantities tailored to your procurement needs. All orders include batch-specific COA and MSDS.
MT Chemtech manufactures CDI CAS 530-62-1 with a purity of ≥99.0% as verified by HPLC. Each batch is tested for assay, moisture content (Karl Fischer), melting point, and appearance. A Certificate of Analysis (COA) is provided with every shipment.
Yes, we provide full documentation including Certificates of Analysis (COA), Material Safety Data Sheets (MSDS), and Technical Data Sheets (TDS) for all CDI shipments. Batch-specific COAs are generated per lot. You can request documents via email at sales@mtchemtech.com or through our website.
We export Carbonyldiimidazole (CDI) to the USA, Canada, Germany, UK, France, Netherlands, Italy, China, Japan, South Korea, Singapore, UAE, Saudi Arabia, Brazil, and over 40 countries. We handle FOB, CIF, and DDP shipping terms with full hazardous-goods compliance.
Yes, 1,1′-Carbonyldiimidazole is recognized as one of the safest and most effective solid alternatives to phosgene (COCl₂) and triphosgene. CDI reacts with carboxylic acids, amines, and alcohols under mild conditions, releasing only carbon dioxide and imidazole as by-products — both relatively innocuous.
CDI is used in the commercial synthesis of blockbuster drugs including Rivaroxaban (Xarelto), Linezolid (Zyvox), Dabigatran (Pradaxa), Apixaban (Eliquis), Lenalidomide (Revlimid), and Ezetimibe (Zetia). It is essential for peptide coupling, carbamate formation, urea synthesis, and β-lactam ring closure.
CDI is moisture-sensitive, so we pack it in sealed fiber drums with double PE liners and a nitrogen blanket. HDPE bottles and amber glass packs are also available. All export containers include desiccant and are labeled with batch numbers, handling instructions, and hazard classifications compliant with IATA and IMDG regulations.
You can request a quotation by filling out the inquiry form on our website, emailing sales@mtchemtech.com, or calling +91-8125120593. Please include your desired quantity, delivery destination, and any specific purity or packing requirements. We respond to all inquiries within 24 business hours.
